GlaxoSmithKline plc (GSK) is a British multinational pharmaceutical company based in London, England. GSK was founded in 2000 through the merger of GlaxoWellcome and Smithclean Beecham, and was the sixth largest pharmaceutical company in the world according to Forbes magazine as of 2019, after Pfizer, Novartis, Roche, Sanofi, merck & GSK is the tenth largest pharmaceutical company #296 the 2019 Fortune 500, ranked behind other pharmaceutical companies including China Resources, Johnson & Johnson, Roche, Sionofer, Pfizer, Novartis, Bayer, Merck, and Sanofi. As of August 2016, the market capitalization stood at £81 billion (about US$107 billion), the fourth largest on the London Stock Exchange. It has a secondary listing on the New York Stock Exchange. the company developed its first malaria vaccine, RTS,S, which it said in 2014 it would save five percent above the cost. The old products developed in GSK include many of the who's list of essential medicines, such as amoxicillin, merkatbopurin, pyrimethamine, and zeldofudine. In 2012, GSK pleaded guilty to promoting drugs for unapproved uses, failing to report safety data, and bribes to doctors in the United States and agreed to pay a $US3 billion (£1.9 billion) settlement. This was the largest health-care fraud to date in that country and the largest settlement by a pharmaceutical company.