Amgen Inc. (formerly Applied Molecular Genetics Inc.) is an American multinational biopharmaceutical company based in Thousand Oaks, California. One of the largest independent biotechnology companies in the world, Amgen was founded in Thousand Oaks, California, in 1980. Amgen's Thousand Oaks in 2017 had 5,125 employees (7.5% of the city's total labor) and included hundreds of scientists, making Amgen the largest employer in Ventura County. It focuses on molecular biology and biochemistry, and its goal is to provide healthcare business based on recombinant DNA technology. In 2018, the company's best-selling product lines were Neulasta, an immune blocker used to prevent infection in patients undergoing chemotherapy for cancer and Enbrel, a tumor necrosis factor used in the treatment of rheumatoid arthritis and other autoimmune diseases. Other products include Ibogen, Aransp, Sensipar/Mimpara, Nplate, Vectibix, Prolia and XGEVA. Amgen sponsors the California tour. the word AMGen is portmanteau of the company's original name, Applied Molecular Genetics, which became the official name of the company in 1983 (three years after its founding and coincides with the initial public offering). The company's first CEO, from 1980, was co-founder George B. Rathman, followed by Gordon M. Binder in 1988, followed by Kevin W. Sher in 2000. Robert Bradway became President and CEO in May 2012 after Cher retired. The company has made at least five major corporate acquisitions.